News & Research
The Siggy Blog
Expert articles on medications, conditions, and the future of mental healthcare, from the team building it.
How Long Does Trintellix Take to Work? Mood vs Focus Timelines
How long Trintellix takes to work: when mood starts to shift, why full effect takes 4 weeks or more, how focus changes separately, and when to reassess.
Trintellix Dosage: 10 mg, 20 mg, or 5 mg? The Real Tradeoff
Trintellix dosage explained: why most people start at 10 mg, what 20 mg adds, when 5 mg makes sense, and how nausea rises with each step up.
Trintellix vs Lexapro: What the Evidence Says About Brain Fog
Trintellix vs Lexapro for depression's cognitive symptoms: what the trials show on focus and brain fog, how side effects differ, and when prescribers switch.
Trintellix Side Effects: Nausea Timeline
Nausea is Trintellix's signature side effect. Here's why it peaks in week one, when it typically fades, and what to do if it does not.
Trintellix for Depression: What Makes It Different and What the Evidence Shows
Trintellix blocks serotonin reuptake and acts on serotonin receptors directly. Learn how it compares, its real side effect rates, dosing, and who it may suit.