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How Long Does Prozac Take to Work? Steady State to Week 8

Prozac can start helping in 1 to 2 weeks, but it takes 4 to 5 weeks to reach steady state. Here's what its long half-life means and why week 8 matters.

September 24, 2026Prozac (Fluoxetine)Prozac TimelineAntidepressant TimelineSSRIs