News & Research
The Siggy Blog
Expert articles on medications, conditions, and the future of mental healthcare, from the team building it.
Prozac Side Effects: What Fades in 2 Weeks and What Lasts
Prozac side effects like nausea and jitters often ease in weeks, while others can last. See FDA label rates, early activation, and what the long half-life means.
Paxil vs Lexapro: Weight, Sleepiness, and Stopping Compared
Paxil vs Lexapro compared on tolerability, using head-to-head trials: side effects, weight gain, sleepiness, sexual effects, and how hard each is to stop.
Zoloft Weight Gain: What Changes Early and What Lasts
Zoloft often dulls appetite early, then weight can drift up slowly over years. See what the largest studies show and what to track with your prescriber.
Sexual Side Effects of SSRIs: Why They Happen and What Patients Can Do
Sexual dysfunction affects up to 80% of people on SSRIs, but most never mention it to their prescriber. Here is why it happens, which medications cause more problems, and five evidence-based strategies that actually work.
Why So Many Patients Stop Anxiety Medication Because of Side Effects (and the Alternative)
Side effects cause about 1 in 12 people to stop anxiety medication early. Here is what the research shows about why it happens and what actually changes outcomes.
Side Effect Tracker: The 5 Categories Patients Most Often Forget to Log
Most patients track physical side effects. The five categories that actually drive treatment decisions are the ones nobody asks about.
Zoloft Side Effects in the First 2 Weeks vs Long-Term: Knowing the Difference
Nausea and insomnia from Zoloft often resolve. Sexual side effects usually do not. Here's how to tell which side effects will pass and which need clinical attention.