News & Research
The Siggy Blog
Expert articles on medications, conditions, and the future of mental healthcare, from the team building it.
Cymbalta Withdrawal: Why the Capsule Makes Tapering Hard
Cymbalta withdrawal often comes down to step size. See why 20, 30, and 60 mg capsules make tapering tricky, and how prescribers build smaller, safer steps.
Mirtazapine for Sleep and Appetite: When Sedation Is the Point
Mirtazapine's drowsiness and appetite boost can help depression with insomnia or weight loss. See what trials show, why benefits may fade, and how dosing works.
Pristiq Withdrawal: Why the 25 mg Step Exists and Its Limits
Pristiq's 25 mg tablet was made for tapering, but a one-week step barely beat stopping cold. Learn the symptoms, timeline, and how prescribers plan slower steps.
Antidepressants and Pregnancy: What the Updated Evidence Actually Says
An FDA panel in July 2025 raised alarm about SSRIs in pregnancy. Here is what the current clinical evidence says, what the real risks are, and why untreated depression may pose a greater threat than the medication.
Is Lexapro an Antidepressant? The Quick Answer Plus What Patients Should Know
Yes, Lexapro is an antidepressant. It is also FDA-approved for anxiety. Here is what escitalopram actually does, why prescribers reach for it, what the side effects are, and how it compares to similar medications.
SSRI Medications Compared: A Side-by-Side Look at the Major Options
All six major SSRIs work through the same mechanism but differ significantly in half-life, drug interactions, side effect profiles, and discontinuation risk. Here is a clinical comparison.
Sexual Side Effects of SSRIs: Why They Happen and What Patients Can Do
Sexual dysfunction affects up to 80% of people on SSRIs, but most never mention it to their prescriber. Here is why it happens, which medications cause more problems, and five evidence-based strategies that actually work.
Online Psychiatric Care for People Already on Medication: The Continuity Question
Switching to online psychiatric care when you are already on an antidepressant raises specific questions. Here is what responsible continuity of care actually looks like for established patients.
Psychiatric Medication Management Online for Treatment-Resistant Patients
If you have tried two antidepressants without lasting relief, you may not have a treatment-resistant brain. You may have an under-evaluated treatment history. Here is what that difference means.