News & Research
The Siggy Blog
Expert articles on medications, conditions, and the future of mental healthcare, from the team building it.
What Is a Mental Status Exam? What Psychiatrists Look For
A mental status exam is psychiatry's version of a physical exam. Here is what it covers, why each part matters, and what it means for your diagnosis.
The Genetic Factors of Depression: What Your DNA Tells You
Depression is not caused by one broken gene. Here is what twin studies, large genetic studies, and decades of research actually show about DNA and depression risk.
What Causes Treatment-Resistant Depression? The Biology Behind It
Treatment-resistant depression is not the same for every person. Here is what the research shows about the neurobiological, genetic, and pharmacological mechanisms that cause some depression to resist standard treatment.
Is PTSD Neurodivergent? The Emerging Science
PTSD is not officially classified as neurodivergent. But it produces measurable, lasting neurological changes in three key brain regions. Here is what the research says, where the debate stands, and what it means for treatment.
Genetic Testing for Psychiatric Medications: Is It Worth It?
Pharmacogenomic testing analyzes the genes that control how your body processes psychiatric medications. Here is what the evidence says about when it helps, when it does not, and who the data most strongly supports.
PHQ-9 Depression Screening: How Doctors Actually Use the Score
The PHQ-9 is more than a checklist. Here is how doctors use your score to screen, measure severity, guide treatment decisions, and know when to change your plan.