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What Is Treatment-Resistant Depression? Signs You Have It and What to Do Next

Treatment-resistant depression (TRD) is defined as depression that doesn't improve after two or more adequate antidepressant trials. About 30% of people with major depression meet this definition. Here is what comes next.

June 18, 2026TRD SignsFailed AntidepressantsEsketamine TreatmentAntidepressant ResistanceDepression Next Steps