News & Research
The Siggy Blog
Expert articles on medications, conditions, and the future of mental healthcare, from the team building it.
Prozac Side Effects: What Fades in 2 Weeks and What Lasts
Prozac side effects like nausea and jitters often ease in weeks, while others can last. See FDA label rates, early activation, and what the long half-life means.
How Long Do Antidepressants Take to Work? Why the First Weeks Feel Like Nothing Is Happening
Most antidepressants take 4 to 8 weeks to work, and sleep or energy often improves before mood. See the week-by-week timeline and when to call your prescriber.
Pristiq for Depression: What the First Weeks Should Look Like
Pristiq (desvenlafaxine) is an SNRI for depression. See how well it works, which side effects to expect, why week two matters, and what to know before stopping.
Starting an Antidepressant: What the First 8 Weeks Look Like
What really happens in your first 8 weeks on an antidepressant: when side effects start, the week-4 checkpoint guidelines use, and when to call your prescriber.