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The Siggy Blog

Expert articles on medications, conditions, and the future of mental healthcare, from the team building it.

Prozac for Patients Who Forget Doses: Why Its Long Half-Life Matters

Fluoxetine has the longest half-life of any SSRI. A single missed dose rarely disrupts treatment the way it does with paroxetine or venlafaxine. Here is the pharmacology and what it means for real-world adherence.

June 1, 2026Prozac (Fluoxetine)SSRI Half-LifeDrug EducationMedication AdherenceSSRI Comparison