News & Research
The Siggy Blog
Expert articles on medications, conditions, and the future of mental healthcare, from the team building it.
Pristiq vs Lexapro: SNRI or SSRI First?
Pristiq vs Lexapro, compared on evidence: how the SNRI and SSRI differ in dosing, side effects, interactions, and anxiety use, and who each one suits first.
Effexor vs Zoloft: How Prescribers Decide
Effexor vs Zoloft: how the SNRI and SSRI compare on effectiveness, side effects, blood pressure, and stopping, and why prescribers often start with one first.
Effexor vs Lexapro: Where the SNRI Effect Actually Kicks In
Effexor acts much like an SSRI at 75 mg and adds norepinephrine effects at higher doses. See how it compares with Lexapro on benefit, side effects, and stopping.
Cymbalta vs Lexapro: When Doctors Choose an SNRI Instead
Cymbalta vs Lexapro compared: pain evidence, side effects, and why stopping Cymbalta can be harder. Learn when a prescriber may pick an SNRI over an SSRI.
SNRI vs. SSRI: Why the Right Antidepressant Is the One That Fits, Not the One That's Stronger
SSRIs and SNRIs work about equally well for depression. See how they differ on pain, blood pressure, side effects, and stopping, and how prescribers choose.