News & Research
The Siggy Blog
Expert articles on medications, conditions, and the future of mental healthcare, from the team building it.
Hydroxyzine Dosage for Anxiety and Sleep: Why Less Often Works
Hydroxyzine's label allows up to 400 mg a day, but sedation climbs faster than benefit. Learn as-needed dosing, the EU's 100 mg cap, and next-day grogginess.
Mirtazapine for Sleep and Appetite: When Sedation Is the Point
Mirtazapine's drowsiness and appetite boost can help depression with insomnia or weight loss. See what trials show, why benefits may fade, and how dosing works.
Melatonin for Sleep: Dosage, Timing, and What Actually Works
Most people take melatonin at the wrong dose and the wrong time. A 2024 meta-analysis of 26 RCTs shows what actually optimizes its sleep-promoting effects.
Trazodone for Sleep: A Patient's Plain-English Guide to Low-Dose Use
Trazodone is one of the most prescribed sleep aids in the United States despite having no FDA approval for insomnia. Here is how low doses work, who they help, and what to watch for.
Hydroxyzine for Sleep and Anxiety: Tracking Sedation, Tolerance, and Effectiveness
Hydroxyzine works for short-term sleep and anxiety. Here is how it works, when tolerance becomes a concern, and what your prescriber should be monitoring closely.