News & Research
The Siggy Blog
Expert articles on medications, conditions, and the future of mental healthcare, from the team building it.
FeaturedMedications
Wellbutrin vs Prozac for Energy and Focus: What Trials Show
Wellbutrin and Prozac treat depression equally well, but they differ on fatigue, sleepiness, activation, and sexual side effects. See what the trials found.
September 24, 2026Wellbutrin (Bupropion)Prozac (Fluoxetine)Wellbutrin vs ProzacAntidepressant Comparison
MedicationsSeptember 24, 2026
How Long Does Prozac Take to Work? Steady State to Week 8
Prozac can start helping in 1 to 2 weeks, but it takes 4 to 5 weeks to reach steady state. Here's what its long half-life means and why week 8 matters.
Prozac (Fluoxetine)Prozac TimelineAntidepressant TimelineSSRIs
MedicationsJune 1, 2026
Prozac for Patients Who Forget Doses: Why Its Long Half-Life Matters
Fluoxetine has the longest half-life of any SSRI. A single missed dose rarely disrupts treatment the way it does with paroxetine or venlafaxine. Here is the pharmacology and what it means for real-world adherence.
Prozac (Fluoxetine)SSRI Half-LifeDrug EducationMedication AdherenceSSRI Comparison