News & Research
The Siggy Blog
Expert articles on medications, conditions, and the future of mental healthcare, from the team building it.
FeaturedMedications
Nortriptyline Side Effects, Heart Checks, and Blood Levels
Nortriptyline side effects explained: dry mouth and other anticholinergic effects, how it affects your heart, why blood levels matter, and when to call.
October 6, 2026NortriptylineTricyclic AntidepressantsAnticholinergic Side EffectsMedication MonitoringPharmacogenomics
MedicationsSeptember 26, 2026
Pristiq vs Effexor: How Metabolism Shapes Which One Fits You
Pristiq is the active compound your body makes from Effexor. See how genes, other medications, and kidney or liver health change which one fits you best.
Pristiq DesvenlafaxineEffexor (Venlafaxine)Antidepressant ComparisonPharmacogenomicsVenlafaxine Metabolism
Clinical & ResearchJune 30, 2026
What Causes Treatment-Resistant Depression? Biology and Blind Spots
If two antidepressants haven't helped, something specific may be in the way. Learn the biological and practical causes of treatment-resistant depression.
Treatment-Resistant DepressionPseudo-ResistanceBipolar MisdiagnosisNeuroinflammation DepressionPharmacogenomics
Clinical & ResearchJune 22, 2026
Genetic Testing for Psychiatric Medications: What It Can and Can't Tell You
Pharmacogenomic tests show how your genes may affect some antidepressants, but trial benefits are modest. Learn who testing helps and how to use results safely.
PharmacogenomicsPsychiatric MedicationsGenetic TestingAntidepressant SelectionPrecision Psychiatry