News & Research
The Siggy Blog
Expert articles on medications, conditions, and the future of mental healthcare, from the team building it.
FeaturedMedications
Antidepressant Not Working After 8 Weeks: A Doctor-Reviewed Decision Path
Eight weeks on an antidepressant with no response is a clinical signal, not a dead end. Here is the doctor-reviewed decision path for what happens next.
June 1, 2026Antidepressant Not WorkingSSRITreatment-Resistant DepressionMedication Adjustment
MedicationsMay 29, 2026
Antidepressant Not Working? 3 Patterns to Check Before You Switch
Before switching antidepressants, three clinical patterns explain most cases of apparent treatment failure. Here is how to check each one before making any changes.
Antidepressant Not WorkingTreatment-Resistant DepressionSSRIMedication Adjustment
MedicationsMay 29, 2026
Starting an Antidepressant: What the First 8 Weeks Look Like
What really happens in your first 8 weeks on an antidepressant: when side effects start, the week-4 checkpoint guidelines use, and when to call your prescriber.
Starting AntidepressantsAntidepressant Side EffectsSSRI TimelineMedication AdjustmentAntidepressant TimelineAntidepressants