News & Research
The Siggy Blog
Expert articles on medications, conditions, and the future of mental healthcare, from the team building it.
How Long Does Depression Last? Why the Answer Isn't One Number
A depression episode often lasts 3 to 4 months, but many run longer. See what shapes recovery, how treatment changes the timeline, and how to prevent relapse.
Bipolar Depression vs. Depression: Why the Difference Lives in Your History
Bipolar depression can look identical to major depression. Learn the history clues that tell them apart and why the difference changes treatment.
Trintellix for Depression: What Makes It Different and What the Evidence Shows
Trintellix blocks serotonin reuptake and acts on serotonin receptors directly. Learn how it compares, its real side effect rates, dosing, and who it may suit.
Am I Depressed? How to Tell and What to Do Next
Not sure if it's depression or a rough patch? Learn the symptoms clinicians look for, the signs that don't look like sadness, and what to do next.
What Causes Depression? What the Science Shows Beyond the Chemical Imbalance
Depression isn't simply low serotonin. See what research shows about genes, early adversity, stress, inflammation, and sleep, and what it means for treatment.
What Is Depression? Symptoms, Causes, and Why Help Takes So Long
Depression is a common, treatable medical condition. Learn the symptoms, types, and causes, how it's treated, and why staying with treatment matters.
Major Depressive Disorder: Symptoms, Diagnosis, and the Weeks That Shape Treatment
What major depressive disorder is, how clinicians diagnose it, which treatments have the strongest evidence, and why the first few months of care matter so much.