News & Research
The Siggy Blog
Expert articles on medications, conditions, and the future of mental healthcare, from the team building it.
Hydroxyzine for Sleep Isn't a Long-Term Insomnia Fix
Hydroxyzine is used off-label for sleep. Learn what the research shows, why next-day grogginess happens, how fast tolerance builds, and safer long-term options.
Amitriptyline for Sleep: A Common Off-Label Habit With Thin Proof
Low-dose amitriptyline is often prescribed off-label for insomnia. See what the first placebo-controlled trial found, what guidelines say, and who needs caution.
Clonidine for Sleep Can Help Some People, and Stopping It Takes a Plan
Clonidine is used off-label for sleep in ADHD and PTSD. See what the evidence shows, the side effects, and why stopping suddenly can spike blood pressure.
Waking Up at 3 AM: Anxiety, Cortisol, and What Actually Helps
Waking up at 3 AM is common, and cortisol is only part of the story. Learn how sleep cycles, anxiety, and alcohol drive it, and why CBT-I is the first-line fix.
Zoloft Insomnia: Why It Happens and Dose Timing Fixes
Insomnia affects 20% of people on Zoloft vs 13% on placebo. Learn why sertraline disrupts sleep, how long it lasts, and how dose timing and CBT-I can help.
Gabapentin for Sleep: Off-Label Evidence and Risks
Gabapentin isn't FDA-approved for insomnia, but it's often used for sleep. See what the slow-wave sleep studies show, who it may fit, and the misuse risks.
Magnesium Glycinate for Sleep: What Trials Actually Show
Does magnesium glycinate help you sleep? We grade the trial evidence, explain what glycine adds, and cover dosing limits, safety, and when to seek care.
Seroquel for Sleep: Why Low-Dose Off-Label Use Is Controversial
Seroquel makes most people sleepy, but major guidelines advise against it for insomnia. See what trials show, the metabolic and heart risks, and better options.
Xanax for Sleep: Why It Fades Fast and What Works Instead
Xanax can knock you out, but it isn't approved for insomnia. See what sleep-lab research shows about tolerance and rebound, plus options that work longer.
Melatonin for Sleep: The Right Dose, Timing, and Who It Helps
Melatonin works best for timing problems like jet lag, not chronic insomnia. See what research says about dose, timing, label accuracy, and SSRI interactions.