News & Research
The Siggy Blog
Expert articles on medications, conditions, and the future of mental healthcare, from the team building it.
FeaturedMedications
Does Hydroxyzine Cause Weight Gain? What the Evidence Says
Hydroxyzine looks close to weight-neutral in trials, with weight gain in 12% vs 10% on placebo. See the label, the antihistamine data, and what to do.
November 3, 2026Hydroxyzine (Vistaril)Hydroxyzine Side EffectsAntihistamine Weight GainNon-Controlled Anxiety MedicationAnxiety Medication
MedicationsSeptember 18, 2026
Hydroxyzine Side Effects and Next-Day Grogginess
Hydroxyzine's sedation curve explains why grogginess can linger into the next morning, and how tolerance changes the picture over time.
Hydroxyzine (Vistaril)Hydroxyzine Side EffectsAntihistamine SedationMedication Monitoring
MedicationsJune 18, 2026
Hydroxyzine for Anxiety: How Well It Works and Who It Fits
Hydroxyzine can ease anxiety within 30 minutes and isn't a controlled substance. See what trials found, how doses compare, and the heart rhythm warning.
Hydroxyzine DosingHydroxyzine Side EffectsAnxiety ReliefNon-Benzodiazepine Anxiety TreatmentAntihistamine AnxietyAnxiety Medication