News & Research
The Siggy Blog
Expert articles on medications, conditions, and the future of mental healthcare, from the team building it.
FeaturedMedications
Guanfacine vs Clonidine: Sedation, Duration, and Typical Uses
Guanfacine and clonidine are both alpha-2 agonists for ADHD, but they differ in sedation, how long a dose lasts, and rebound risk. See how they compare.
September 25, 2026Guanfacine (Intuniv)ClonidineAlpha-2 AgonistsADHD Medication ComparisonNon-Stimulant ADHD
MedicationsSeptember 24, 2026
Guanfacine Dosage: Why Prescribers Raise It 1 mg at a Time
Guanfacine ER starts at 1 mg and rises no more than 1 mg a week. Learn the weight-based targets, why sedation peaks at each step, and how to taper safely.
Guanfacine (Intuniv)Guanfacine DosageNon-Stimulant ADHDADHD Medication
MedicationsSeptember 18, 2026
Guanfacine Side Effects: Sedation Timeline
Guanfacine's most common side effect is sedation, and it usually follows a predictable curve. Here's why tiredness peaks early and what fades within a few weeks.
Guanfacine (Intuniv)Guanfacine Side EffectsNon-Stimulant ADHDMedication Monitoring
MedicationsMay 29, 2026
Guanfacine for ADHD: The Non-Stimulant That Helps With Sleep and Focus
Guanfacine (Intuniv) treats ADHD through a different mechanism than stimulants. Here's how it works, who it helps, and what to track once you start it.
Guanfacine (Intuniv)Non-Stimulant ADHDDrug EducationADHD Medication