News & Research
The Siggy Blog
Expert articles on medications, conditions, and the future of mental healthcare, from the team building it.
FeaturedConditions & Diagnoses
What Is Depression? Symptoms, Causes, and Why Getting the Right Help Takes So Long
Depression affects 21 million U.S. adults, yet most wait years for help. A psychiatrist explains what depression is, its symptoms, causes, types, and how continuous care changes outcomes.
June 22, 2026What Is DepressionDepression SymptomsMajor Depressive DisorderDepression Treatment OptionsDepression Causes
Treatment & TherapyJune 19, 2026
Treatment-Resistant Depression Options: Beyond Standard Antidepressants
When two or more antidepressants fail at adequate dose and duration, TRD-specific options open up. Here is what the clinical evidence says about TMS, esketamine, ECT, MAOIs, and augmentation.
Treatment-Resistant DepressionTMS for DepressionEsketamine TreatmentBeyond AntidepressantsDepression Treatment Options
Conditions & DiagnosesJune 18, 2026
What Is Major Depressive Disorder? Symptoms, Diagnosis, and Treatment
MDD is more than feeling sad. Here is what the DSM-5 criteria say, how clinicians diagnose it, and which treatments have the strongest evidence.
Major Depressive DisorderDepression SymptomsDepression Treatment OptionsMood DisordersMDD Diagnosis