News & Research
The Siggy Blog
Expert articles on medications, conditions, and the future of mental healthcare, from the team building it.
Medication vs. Therapy for Depression: What Works Best?
Antidepressants and therapy both treat depression, and research shows combining them often outperforms either alone. Here's what the evidence actually says about choosing.
TMS for Treatment-Resistant Depression: What to Expect
Tried two antidepressants and still stuck? Learn who qualifies for TMS, realistic results, what predicts success, and what each week of treatment is like.
Treatment-Resistant Depression Options: How to Choose Your Next Step
Two antidepressants didn't help? Compare add-on medications, esketamine, IV ketamine, TMS, ECT, and therapy, and see which option fits your situation.
What Is Treatment-Resistant Depression? How to Tell Whether Your Last Two Antidepressants Really Counted
Treatment-resistant depression means two adequate antidepressant trials didn't work. Learn how to audit past trials, the odds at each step, and what comes next.