News & Research
The Siggy Blog
Expert articles on medications, conditions, and the future of mental healthcare, from the team building it.
Medication vs. Therapy for Depression: What Works Best?
Antidepressants and therapy both treat depression, and research shows combining them often outperforms either alone. Here's what the evidence actually says about choosing.
What Is Depression? Symptoms, Causes, and Why Getting the Right Help Takes So Long
Depression affects 21 million U.S. adults, yet most wait years for help. A psychiatrist explains what depression is, its symptoms, causes, types, and how continuous care changes outcomes.
Treatment-Resistant Depression Options: Beyond Standard Antidepressants
When two or more antidepressants fail at adequate dose and duration, TRD-specific options open up. Here is what the clinical evidence says about TMS, esketamine, ECT, MAOIs, and augmentation.
What Is Major Depressive Disorder? Symptoms, Diagnosis, and Treatment
MDD is more than feeling sad. Here is what the DSM-5 criteria say, how clinicians diagnose it, and which treatments have the strongest evidence.