News & Research
The Siggy Blog
Expert articles on medications, conditions, and the future of mental healthcare, from the team building it.
FeaturedMedications
Latuda Dosage: Why the 350-Calorie Rule Changes Your Dose
Latuda starts at 20 mg for bipolar depression, but food decides how much you absorb. See the dose ranges and why a 350-calorie meal roughly doubles exposure.
September 25, 2026Latuda (Lurasidone)Latuda DosageBipolar Depression TreatmentAntipsychotic Dose ResponseFood-Drug Interactions
MedicationsSeptember 25, 2026
Rexulti Dosage for Depression: Why 2 mg Is the Usual Target
Rexulti for depression starts at 0.5 or 1 mg and usually targets 2 mg. See what each dose did in trials, which side effects rise with dose, and what lowers it.
Rexulti (Brexpiprazole)Rexulti DosageAntidepressant AugmentationAntipsychotic Dose Response
MedicationsSeptember 17, 2026
Seroquel Side Effects by Dose: Why Low and High Differ
Seroquel's side effects change with dose because of receptor biology, not chance. Here is why low-dose sedation and high-dose antipsychotic effects look so different.
Seroquel (Quetiapine)Seroquel Side EffectsQuetiapine DosingAntipsychotic Dose Response