News & Research
The Siggy Blog
Expert articles on medications, conditions, and the future of mental healthcare, from the team building it.
Does Trazodone Cause Weight Gain? Sleep vs Depression Doses
Trazodone weight gain is uncommon, but most data come from depression doses. See what trials show, why sleep doses differ, and what to track.
Paxil vs Lexapro: Weight, Sleepiness, and Stopping Compared
Paxil vs Lexapro compared on tolerability, using head-to-head trials: side effects, weight gain, sleepiness, sexual effects, and how hard each is to stop.
Mirtazapine Weight Gain: How Much, How Fast, and What Helps
Mirtazapine raised appetite in 17% of people in trials. See how much weight gain studies show, what dose does and doesn't change, and ways to manage it.
Zoloft Weight Gain: What Changes Early and What Lasts
Zoloft often dulls appetite early, then weight can drift up slowly over years. See what the largest studies show and what to track with your prescriber.
Lexapro and Weight Gain: What to Actually Expect
See how Lexapro's weight outcomes compared with sertraline in a 183,000-patient study, possible contributors, and what is modifiable.
Wellbutrin and Weight: What the Clinical Evidence Shows
Wellbutrin is one of the few antidepressants linked to weight loss rather than weight gain. Here is what the mechanism and the clinical trial data actually show.