News & Research
The Siggy Blog
Expert articles on medications, conditions, and the future of mental healthcare, from the team building it.
How Long Does Zoloft Take to Work? A Week-by-Week Timeline
Zoloft can ease anxiety and sleep before low mood lifts. See what changes in weeks 1 to 12, when to check in early, and why week 8 is the real checkpoint.
Wellbutrin Side Effects: Timeline From Week 1 to Month 3
Wellbutrin side effects like insomnia often start in the first week. See what trial data show fades by month 3, what lingers, and the seizure rules to know.
How Long Does Effexor Take to Work? Why the Dose Matters
How long does Effexor take to work? See the week-by-week timeline, why dose increases shift the clock, what early improvement predicts, and when to reassess.
How Long Does Paxil Take to Work? Early Relief vs Full Effect
How long does Paxil take to work? See why anxiety often eases first, how the timeline shifts by condition and dose, and what weeks 2 and 4 can tell you.
How Long Does Trintellix Take to Work? Mood vs Focus Timelines
How long Trintellix takes to work: when mood starts to shift, why full effect takes 4 weeks or more, how focus changes separately, and when to reassess.
How Long Does Prozac Take to Work? Steady State to Week 8
Prozac can start helping in 1 to 2 weeks, but it takes 4 to 5 weeks to reach steady state. Here's what its long half-life means and why week 8 matters.
How Long Do Antidepressants Take to Work? Why the First Weeks Feel Like Nothing Is Happening
Most antidepressants take 4 to 8 weeks to work, and sleep or energy often improves before mood. See the week-by-week timeline and when to call your prescriber.
Wellbutrin for Anxiety: A Realistic Timeline, Week by Week
Wellbutrin isn't approved for anxiety, but it's often used when anxiety and depression overlap. Here's a realistic timeline and what the evidence shows.
Starting an Antidepressant: What the First 8 Weeks Look Like
What really happens in your first 8 weeks on an antidepressant: when side effects start, the week-4 checkpoint guidelines use, and when to call your prescriber.