News & Research
The Siggy Blog
Expert articles on medications, conditions, and the future of mental healthcare, from the team building it.
Atypical Antidepressants Aren't One Class, and That's the Point
Bupropion, mirtazapine, trazodone, vortioxetine, and vilazodone each work differently. Compare how they work, their side effects, and who each may suit.
Amitriptyline Side Effects: Why Dose and Age Change the Whole Picture
Amitriptyline side effects depend heavily on dose and age. Learn about sedation, dry mouth, heart rhythm cautions, and why older adults face extra risks.
Wellbutrin and Caffeine: Why Your Usual Coffee Can Hit Differently Now
Wellbutrin and caffeine both stimulate your nervous system. Learn how they stack for jitters, sleep, blood pressure, and seizure threshold, and how much is reasonable.
Zoloft Diarrhea: Why It Happens and How Long It Lasts
Diarrhea is one of Zoloft's most common side effects. Learn why sertraline affects your gut, how long it tends to last, what helps, and when to call for care.
Tricyclic Antidepressants: What They Are and When They Are Still Used
How tricyclic antidepressants work, why SSRIs replaced them as a first choice, where they still help with pain, sleep, and OCD, and how to use them safely.
Celexa Side Effects: The 40 mg Ceiling and Heart Rhythm Warning
Celexa side effects explained: what's common, how the QT heart rhythm warning set a 40 mg limit, why adults over 60 cap at 20 mg, and when to call.
Zoloft Side Effects: What Fades, What Persists, When to Call
Zoloft side effects by the numbers: label rates vs placebo, which ones usually fade, which tend to persist, and the warning signs that mean call your prescriber.
Does Wellbutrin Cause Hair Loss? What the Reports Show
Wellbutrin can trigger temporary shedding called telogen effluvium. See how often it happens, when it starts, whether hair grows back, and when to switch.
Trazodone Side Effects: Grogginess, Dizziness, and Priapism
Trazodone side effects change with dose. Learn why it causes grogginess and dizziness, what the priapism warning means, and which symptoms need a call today.
Wellbutrin Side Effects: Timeline From Week 1 to Month 3
Wellbutrin side effects like insomnia often start in the first week. See what trial data show fades by month 3, what lingers, and the seizure rules to know.
Viibryd Side Effects: What the Food Requirement Really Does
Viibryd's most common side effects are diarrhea and nausea. See what the trials found, what the take-with-food rule actually does, and what to watch early on.
Pristiq for Depression: What the First Weeks Should Look Like
Pristiq (desvenlafaxine) is an SNRI for depression. See how well it works, which side effects to expect, why week two matters, and what to know before stopping.
Trintellix for Depression: What Makes It Different and What the Evidence Shows
Trintellix blocks serotonin reuptake and acts on serotonin receptors directly. Learn how it compares, its real side effect rates, dosing, and who it may suit.
Lexapro vs. Wellbutrin: The Real Difference Is How They Feel, Not How Strong They Are
Lexapro and Wellbutrin work about equally well for depression. Compare anxiety relief, sexual side effects, weight, and seizure risk to see which may fit you.
SSRI Sexual Side Effects: Why They Happen and What Actually Helps
Why SSRIs can affect desire, arousal, and orgasm, how common it really is, which fixes have the best evidence, and how to raise it with your prescriber.
Starting an Antidepressant: What the First 8 Weeks Look Like
What really happens in your first 8 weeks on an antidepressant: when side effects start, the week-4 checkpoint guidelines use, and when to call your prescriber.
Side Effect Tracker: The 5 Categories Patients Most Often Forget to Log
Most patients track physical side effects. The five categories that actually drive treatment decisions are the ones nobody asks about.
Trazodone Side Effects: The Daytime Effects Patients Don't Realize Are Reportable
Morning grogginess, dizziness when standing, and cognitive fog from trazodone are rarely reported. Here's what qualifies as a reportable side effect and why it changes your treatment.