News & Research
The Siggy Blog
Expert articles on medications, conditions, and the future of mental healthcare, from the team building it.
Pristiq vs Lexapro: SNRI or SSRI First?
Pristiq vs Lexapro, compared on evidence: how the SNRI and SSRI differ in dosing, side effects, interactions, and anxiety use, and who each one suits first.
SNRI vs. SSRI: Why the Right Antidepressant Is the One That Fits, Not the One That's Stronger
SSRIs and SNRIs work about equally well for depression. See how they differ on pain, blood pressure, side effects, and stopping, and how prescribers choose.
Lexapro vs Prozac: How These Two SSRIs Really Differ
Lexapro and Prozac are both SSRIs, but they differ in FDA approvals, half-life, drug interactions, and how they wind down. Here's what the evidence says.
Lexapro vs Zoloft: Differences, Side Effects and Who Should Take Each
Both SSRIs treat depression and anxiety, but they have different FDA approvals, side effect profiles, and clinical fits. A psychiatrist explains what actually separates Lexapro and Zoloft and how the right choice gets made.
Genetic Testing for Psychiatric Medications: What It Can and Can't Tell You
Pharmacogenomic tests show how your genes may affect some antidepressants, but trial benefits are modest. Learn who testing helps and how to use results safely.
First-Line vs Second-Line Antidepressants: How Doctors Choose Your Next Step
Not all antidepressants are chosen the same way. Learn how doctors select first-line SSRIs and when second-line options become the right next step for depression treatment.
Wellbutrin vs SSRIs: When Doctors Choose Bupropion First
How Wellbutrin (bupropion) and SSRIs compare on effectiveness, side effects, anxiety, energy, and safety, and how prescribers decide which one to try first.