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The Siggy Blog

Expert articles on medications, conditions, and the future of mental healthcare, from the team building it.

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Lexapro vs Prozac: How Prescribers Actually Choose Between Them

Lexapro and Prozac are both SSRIs, but they behave differently in the body. Here is what the clinical evidence says about efficacy, side effects, half-life, and who each medication suits best.

June 24, 2026Lexapro vs ProzacEscitalopram FluoxetineSSRI ComparisonAntidepressant SelectionDepression Medication Comparison