News & Research
The Siggy Blog
Expert articles on medications, conditions, and the future of mental healthcare, from the team building it.
Lexapro Withdrawal: Symptoms, Timeline, and How to Taper
Lexapro withdrawal explained: common symptoms, when they start and fade, how escitalopram's half-life shapes the timeline, and what slow tapers look like.
Wellbutrin Withdrawal: Symptoms, Timeline, and Tapering
Wellbutrin withdrawal is far less studied than SSRI withdrawal, but case reports show it's real. Learn the signs, timeline, and how it differs from relapse.
Effexor Withdrawal: Why Venlafaxine Is So Hard to Stop
Effexor withdrawal can start within a day of a missed dose. Learn why venlafaxine is hard to stop, how long symptoms last, and how a slower step-down helps.
Brain Zaps: Why They Happen When You Miss or Stop an SSRI
Brain zaps are a common antidepressant withdrawal symptom. Learn why they happen, which drugs cause them most, and how a slower taper can help.
Effexor vs Cymbalta: Dosing, Side Effects, and Stopping Risk
Effexor and Cymbalta are both SNRIs, but they differ in dose range, early nausea, blood pressure, liver cautions, and how hard they are to stop. See the data.
How to Taper Off Wellbutrin: Dose Steps, Timing, and Checks
Tapering off Wellbutrin is usually simpler than stopping an SSRI, but the steps depend on your tablet. See how dose cuts, timing, and monitoring are sequenced.
Paxil vs Zoloft: Why Half-Life Changes the Choice
Paxil vs Zoloft compared on what matters day to day: half-life, missed doses, tapering, weight, sexual side effects, pregnancy, and drug interactions.
Paxil Withdrawal: Why It's Often the Hardest SSRI to Stop
Paxil withdrawal can start within days of stopping. See why paroxetine is harder to stop than most SSRIs, what slow-taper evidence shows, and what to watch.
Cymbalta for Anxiety and Depression: What the First Two Months Actually Look Like
How Cymbalta (duloxetine) treats anxiety and depression, how it compares with SSRIs, which side effects to expect early on, and why tapering off matters.
Antidepressants Guide: Why Staying With Treatment Matters as Much as the Pill You Pick
How antidepressants work, how well they work, how prescribers choose one, which side effects to expect, and why staying on track and tapering slowly matter.