News & Research
The Siggy Blog
Expert articles on medications, conditions, and the future of mental healthcare, from the team building it.
Wellbutrin vs Prozac for Energy and Focus: What Trials Show
Wellbutrin and Prozac treat depression equally well, but they differ on fatigue, sleepiness, activation, and sexual side effects. See what the trials found.
Cymbalta vs Wellbutrin: Choosing for Pain, Energy, or Both
Cymbalta has the pain and anxiety evidence. Wellbutrin favors energy, less weight gain, and fewer sexual side effects. See how your symptoms steer the choice.
Antidepressants: Types, How They Work, and What to Expect
SSRIs are not the only option. A plain-language guide to how antidepressants work, which types exist, what to expect in the first 8 weeks, and why adherence changes everything.
SNRIs vs SSRIs: Which Antidepressant Is Right for You?
SSRIs and SNRIs are both effective for depression and anxiety, but they work differently and suit different clinical profiles. A prescriber-led comparison of when each makes sense.
Lexapro vs Wellbutrin: Comparing Two Popular Antidepressants
Lexapro targets serotonin. Wellbutrin targets dopamine and norepinephrine. Both treat depression effectively, but they differ significantly in how they handle anxiety, sexual side effects, and energy.
Wellbutrin vs SSRIs: When Doctors Choose Bupropion First
Bupropion and SSRIs are both first-line antidepressants, but they work differently and suit different patients. Here is the clinical decision that makes a prescriber reach for one over the other.