News & Research
The Siggy Blog
Expert articles on medications, conditions, and the future of mental healthcare, from the team building it.
Zoloft vs Wellbutrin: How Prescribers Choose the Right Fit
Zoloft vs Wellbutrin compared: similar results for depression, but different fits for anxiety, fatigue, and sexual side effects, plus when they're combined.
Abilify Side Effects: Akathisia, Weight, and Impulse Control
Abilify side effects range from restlessness and weight gain to rare impulse-control urges. See what the FDA boxed warnings mean and which signs need a call.
Rexulti Side Effects: What to Expect as a Depression Add-On
Rexulti side effects center on restlessness and weight gain, which can rise with dose. See the label data, how Rexulti compares with Abilify, and what to watch.
Rexulti Dosage for Depression: Why 2 mg Is the Usual Target
Rexulti for depression starts at 0.5 or 1 mg and usually targets 2 mg. See what each dose did in trials, which side effects rise with dose, and what lowers it.
Vraylar Dosage: Why Each Dose Change Takes Weeks to Settle
Vraylar for depression starts at 1.5 mg, with an option for 3 mg on day 15. Learn why its long-lasting metabolite makes each dose change unfold over weeks.
How Long Does Abilify Take to Work? Add-On vs. Standalone
Abilify can act within days for mania and within one to two weeks as an antidepressant add-on. See what the trials show about timing, dosing, and what to track.
Buspar for Anxiety: How Buspirone Works and Who It Fits
Buspar (buspirone) eases ongoing anxiety without sedation or dependence, but it takes weeks and won't stop a panic attack. Here's what the evidence shows.
What Is Treatment-Resistant Depression? How to Tell Whether Your Last Two Antidepressants Really Counted
Treatment-resistant depression means two adequate antidepressant trials didn't work. Learn how to audit past trials, the odds at each step, and what comes next.