News & Research
The Siggy Blog
Expert articles on medications, conditions, and the future of mental healthcare, from the team building it.
FeaturedMedications
Guanfacine vs Clonidine: Sedation, Duration, and Typical Uses
Guanfacine and clonidine are both alpha-2 agonists for ADHD, but they differ in sedation, how long a dose lasts, and rebound risk. See how they compare.
September 25, 2026Guanfacine (Intuniv)ClonidineAlpha-2 AgonistsADHD Medication ComparisonNon-Stimulant ADHD
MedicationsJune 26, 2026
Stimulant vs Non-Stimulant ADHD Meds: Stronger Isn't Always a Better Fit
Stimulants work faster and, on average, more strongly for ADHD, but non-stimulants suit some adults better. Compare effect sizes, side effects, and heart risk.
ADHD MedicationNon-Stimulant ADHDADHD in AdultsADHD Medication ComparisonADHD Comorbidity
MedicationsJune 22, 2026
Wellbutrin vs. Adderall: How They Compare for ADHD and Depression
Wellbutrin and Adderall both act on dopamine, but they differ in evidence, speed, and risk. See which fits ADHD, depression, or both, and what to ask.
Wellbutrin vs AdderallBupropion for ADHDADHD Medication ComparisonNon-Stimulant ADHDOff-Label Prescribing